MUC4 and MUC5AC are highly specific tumour-associated mucins in biliary tract cancer
نویسندگان
چکیده
منابع مشابه
Expression of membrane-associated mucins MUC1 and MUC4 in major human salivary glands.
Mucins are high molecular weight glycoproteins secreted by salivary glands and epithelial cells lining the digestive, respiratory, and reproductive tracts. These glycoproteins, encoded in at least 13 distinct human genes, can be subdivided into gel-forming and membrane-associated forms. The gel-forming mucin MUC5B is secreted by mucous acinar cells in major and minor salivary glands, but little...
متن کاملGastric MUC5AC and MUC6 are large oligomeric mucins that differ in size, glycosylation and tissue distribution.
Gastric MUC5AC and MUC6 mucins were studied using polyclonal antibodies. Immunohistochemistry showed MUC5AC to originate from the surface epithelium, whereas MUC6 was produced by the glands. Mucins from the surface epithelium or glands of corpus and antrum were purified using CsCl/4M guanidinium chloride density-gradient centrifugation. MUC5AC appeared as two distinct populations at 1.4 and 1.3...
متن کاملAltered Expression of Transmembrane Mucins, MUC1 and MUC4, in Bladder Cancer: Pathological Implications in Diagnosis
PURPOSE Radical changes in both expression and glycosylation pattern of transmembrane mucins have been observed in various malignancies. We and others have shown that MUC1 and MUC4, two transmembrane mucins, play a sentinel role in cell signaling events that drive several epithelial malignancies. In the present study, we investigated the expression profile of MUC1 and MUC4 in the non-neoplastic...
متن کاملMuc5b and Muc5ac are the major oligomeric mucins in equine airway mucus.
Horses frequently suffer from respiratory diseases, which, irrespective of etiology, are often associated with airway mucus accumulation. Studies on human airways have shown that the key structural components of the mucus layer are oligomeric mucins, which can undergo changes of expression and properties in disease. However, there is little information on these gel-forming glycoproteins in hors...
متن کاملMUC5AC and MUC5B Mucins Are Decreased in Cystic Fibrosis Airway Secretions.
Cystic fibrosis (CF) is characterized by progressive airway obstruction. Although it has been postulated that this is due in part to mucus hypersecretion, there are no published data showing an increase in the gel-forming mucins MUC5AC or MUC5B in CF secretions. We used confocal microscopy to assess the amount of mucin-like glycoprotein and DNA in CF sputum and found more mucin in bronchitis sp...
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ژورنال
عنوان ژورنال: British Journal of Cancer
سال: 2008
ISSN: 0007-0920,1532-1827
DOI: 10.1038/sj.bjc.6604364